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Mutation Information
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Mutation Site
|
L214F |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
azvudine (FNC);lamivudine (LAM) |
Literature Information
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PubMed PMID
|
25144636
|
|
Published Year
|
2014 |
|
Journal
|
PloS one |
|
Title
|
Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. |
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Author
|
Wang RR,Yang QH,Luo RH,Peng YM,Dai SX,Zhang XJ,Chen H,Cui XQ,Liu YJ,Huang JF,Chang JB,Zheng YT |
|
Evidence
|
L214F showed high induced resistance correlation with FNC and the frequency of L214F ranged from 30.30% to 100% in P-5 to P-21 variants whereas similar.
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HIV Mutation Detail Information