HIV Mutation Detail Information

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Mutation Information

Mutation Site	L184F
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	K03455.1
Immune Escape	Y
Country	India

Literature Information

PubMed PMID	32669335
Disease	HIV infection/AIDS
Published Year	2020
Journal	Journal of virology
Title	A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex.
Author	Mishra N,Sharma S,Dobhal A,Kumar S,Chawla H,Singh R,Das BK,Kabra SK,Lodha R,Luthra K
Evidence	The L184F mutation altered the trimer conformation by modulating intramolecular interactions stabilizing the trimer apex and led to viral escape from autologous plasma bnAbs and known N160 glycan-targeted bnAbs.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation