HBV Mutation Detail Information

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Mutation Information

Mutation Site	L176V
Mutation Type	Amino acid level
Gene/Protein/Region Type	S

Literature Information

PubMed PMID	21786803
Published Year	2011
Journal	Journal of medicinal chemistry
Title	Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
Author	Yu W,Goddard C,Clearfield E,Mills C,Xiao T,Guo H,Morrey JD,Motter NE,Zhao K,Block TM,Cuconati A,Xu X
Evidence	Because of overlapping open reading frames there are often HBsAg peptide changes that result from the emergence of polymerase drug resistant (DR) mutations, for instance, polymerase mutations M552V, M552I, A529V, T532G, and S551I result in the HBsAg alterations I195M, W196S, L173F, L176V, and V194F, respectively.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation