|
Mutation Information
|
Mutation Site
|
L176V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
Literature Information
|
PubMed PMID
|
15328117
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2004 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. |
|
Author
|
Tenney DJ,Levine SM,Rose RE,Walsh AW,Weinheimer SP,Discotto L,Plym M,Pokornowski K,Yu CF,Angus P,Ayres A,Bartholomeusz A,Sievert W,Thompson G,Warner N,Locarnini S,Colonno RJ |
|
Evidence
|
Substitutions rtT184G and rtS202I resulted in sL176V and sV194F changes in HBsAg, respectively.
|
|
|
HBV Mutation Detail Information