HBV Mutation Detail Information

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Mutation Information

Mutation Site	L175S
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	D
Country	Italy

Literature Information

PubMed PMID	25418031
Disease	HBV infection
Published Year	2015
Journal	Hepatology (Baltimore, Md.)
Title	Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.
Author	Salpini R,Colagrossi L,Bellocchi MC,Surdo M,Becker C,Alteri C,Aragri M,Ricciardi A,Armenia D,Pollicita M,Di Santo F,Carioti L,Louzoun Y,Mastroianni CM,Lichtner M,Paoloni M,Esposito M,D'Amore C,Marrone A,Marignani M,Sarrecchia C,Sarmati L,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence	The remaining five (C48G-V96A-L175S-G185E-V190A) are localized in class I/II-restricted T-cell epitopes, suggesting a role in HBV escape from T-cell-mediated responses.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation