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Mutation Information
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Mutation Site
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L175A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
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Viral Reference
|
K03455.1
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Literature Information
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PubMed PMID
|
33785631
|
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Published Year
|
2021 |
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Journal
|
mBio |
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Title
|
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State. |
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Author
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Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P |
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Evidence
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The cluster 1 mutations with the most dramatic impact on neutralization were L154A, L175A, and I322A, while V134A and I326A had a less marked effect with virtually no effect on trimer-preferring bNAbs (Fig. 3A).
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HIV Mutation Detail Information