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Mutation Information
|
Mutation Site
|
L173F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
Literature Information
|
PubMed PMID
|
18331765
|
|
Disease
|
HBV infection
|
|
Published Year
|
2008 |
|
Journal
|
Journal of hepatology |
|
Title
|
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure. |
|
Author
|
Villet S,Pichoud C,Billioud G,Barraud L,Durantel S,Trépo C,Zoulim F |
|
Evidence
|
Since the S gene of HBV overlaps the polymerase gene, mutations in one gene may result in changes in the other gene. All the mutants harboring rtA181V and rtA181T mutations in the RT domain induced sL173F and sW172stop changes, respectively, in the S gene.
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HBV Mutation Detail Information