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Mutation Information
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Mutation Site
|
L146F |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Nef |
Literature Information
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PubMed PMID
|
31927483
|
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Published Year
|
2020 |
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Journal
|
iScience |
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Title
|
Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation. |
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Author
|
Hirao K,Andrews S,Kuroki K,Kusaka H,Tadokoro T,Kita S,Ose T,Rowland-Jones SL,Maenaka K |
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Evidence
|
Together with the functional data on I132T and I123L/L146F mutations, these suggest that Nef needs to interact with the CD3 zeta chain with a dissociation constant in the μM range to achieve CD3 downregulation.
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HIV Mutation Detail Information