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Mutation Information
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Mutation Site
|
L143A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BRLF1 |
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Combined Mutation
|
rlf1.L143A+rlf1.L144A |
Literature Information
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PubMed PMID
|
21697476
|
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Published Year
|
2011 |
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Journal
|
Journal of virology |
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Title
|
Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. |
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Author
|
Robinson AR,Kwek SS,Hagemeier SR,Wille CK,Kenney SC |
|
Evidence
|
Three other BRLF1 mutants (the L143A, L144A, and L143/144A mutants) were also found to be impaired for interaction with Oct-1 in vitro (data not shown), but since these mutants were found to be unstable when expressed in mammalian cells, they were not investigated further.
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EBV Mutation Detail Information