|
Mutation Information
|
Mutation Site
|
L134W |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp120 |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
fostemsavir |
Literature Information
|
PubMed PMID
|
32160290
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Identification of gp120 polymorphisms in HIV-1 B subtype potentially associated with resistance to fostemsavir. |
|
Author
|
Bouba Y,Berno G,Fabeni L,Carioti L,Salpini R,Aquaro S,Svicher V,Perno CF,Ceccherini-Silberstein F,Santoro MM |
|
Evidence
|
Some fostemsavirv resistance positions positively and significantly correlated with specific gp120 polymorphisms: S375T with I371V;S375M with L134W, I154V and I323T;M475I with K322A;and M426R with G167N, K192T and S195N.
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HIV Mutation Detail Information