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Mutation Information
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Mutation Site
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L131S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Tax |
Literature Information
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PubMed PMID
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25340740
|
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Published Year
|
2014 |
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Journal
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PLoS pathogens |
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Title
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HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation. |
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Author
|
Choi YB,Harhaj EW |
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Evidence
|
To identify cellular proteins ubiquitinated in a Tax-dependent manner Jurkat cells expressing tetracycline-inducible Tax and TaxM22, a mutant (T130A, L131S) impaired in NEMO binding and NF-kappaB activation, were subjected to the UbiScan ubiquitination proteomics platform.
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HTLV1 Mutation Detail Information