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Mutation Information
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Mutation Site
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L131S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Tax |
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Combined Mutation
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tax.L131S+tax.T130A |
Literature Information
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PubMed PMID
|
10438454
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Published Year
|
1999 |
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Journal
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The Journal of biological chemistry |
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Title
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IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. |
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Author
|
Harhaj EW,Sun SC |
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Evidence
|
Interestingly, co-IP assays revealed that while the wild type Tax and M47 both strongly interacted with NEMO/IKKγ (Fig.4, upper panel , lanes 2 and 4 ), only a marginal NEMO/IKKγ binding activity was detected with M22 (lane 3 ).
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HTLV1 Mutation Detail Information