HIV Mutation Detail Information

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Mutation Information

Mutation Site	L122A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	K03455.1

Literature Information

PubMed PMID	33785631
Published Year	2021
Journal	mBio
Title	Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.
Author	Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P
Evidence	Among the other 7 mutations, the most consequential were L122A, F159A, F176A, I307A, and F317A, although two of them, F159A and F317A, showed a discrepancy between a strong effect on anti-CD4-BS MAbs like F105 and VRC01 and only a modest impact on sCD4, suggesting an incomplete opening of the trimer in this region (Fig. 3A).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation