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Mutation Information
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Mutation Site
|
L118S |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E2 |
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Genotype/Subtype
|
HPV2 |
Literature Information
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PubMed PMID
|
22333459
|
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Published Year
|
2012 |
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Journal
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BMC molecular biology |
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Title
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A point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter. |
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Author
|
Gao C,Pan MM,Lei YJ,Tian LQ,Jiang HY,Li XL,Shi Q,Tian C,Yuan YK,Fan GX,Dong XP |
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Evidence
|
Previously we reported a HPV-2 variant from a verrucae vulgaris patient with huge extensive clustered cutaneous, which have five point mutations in its E2 ORF, L118S, S235P, Y287H, S293R and A338V.
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HPV Mutation Detail Information