HIV Mutation Detail Information

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Mutation Information

Mutation Site	L116A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	K03455.1

Literature Information

PubMed PMID	33785631
Published Year	2021
Journal	mBio
Title	Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.
Author	Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P
Evidence	The negligible effect of the L116A mutation on neutralization by sCD4 may be due to a loosening of intracore C4 anchoring to the alpha1-helix in the C1 region, in line with the reported effects of inner-domain layer 1 mutations on the CD4-BS.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation