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Mutation Information
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Mutation Site
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L112A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Nef |
Literature Information
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PubMed PMID
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33109760
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Published Year
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2020 |
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Journal
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mBio |
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Title
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HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation. |
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Author
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Yang Y,Liu W,Hu D,Su R,Ji M,Huang Y,Shereen MA,Xu X,Luo Z,Zhang Q,Liu F,Wu K,Liu Y,Wu J |
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Evidence
|
Moreover, Nef carrying mutations L112A and Y115A increased the secretion of IL-2 in the presence of siR-mouLMP7 (from 91 pg/ml to 188 pg/ml) (Fig. 6D and andE).E).
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HIV Mutation Detail Information