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Mutation Information
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Mutation Site
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L10I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Relevant Drug
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darunavir (DRV) |
Literature Information
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PubMed PMID
|
27992544
|
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Published Year
|
2016 |
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Journal
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PloS one |
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Title
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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
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Author
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Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
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Evidence
|
Unlike the L10F mutation in PR20, L10I in PRS17 does not break the inter-subunit ion pair or diminish the dimer stability, consistent with a very low dimer dissociation constant comparable to that of wild type PR.
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HIV Mutation Detail Information