|
Mutation Information
|
Mutation Site
|
L10I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
lopinavir(LPV);ritonavir |
|
Country
|
Thailand; South Africa; India; Malawi;Tanzania |
Literature Information
|
PubMed PMID
|
27704010
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2016 |
|
Journal
|
Open forum infectious diseases |
|
Title
|
Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clinical Trials Group Protocol A5230. |
|
Author
|
Vardhanabhuti S,Katzenstein D,Bartlett J,Kumarasamy N,Wallis CL |
|
Evidence
|
Among the minor LPV/r-associated mutations present in >10% at SE (L63P, L10I/F/V, and K20R), 71% (15 of 21) remained at VF.
|
|
|
HIV Mutation Detail Information