HIV Mutation Detail Information

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Mutation Information

Mutation Site	L10F
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Relevant Drug	darunavir (DRV)

Literature Information

PubMed PMID	27992544
Published Year	2016
Journal	PloS one
Title	Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.
Author	Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT
Evidence	Unlike the L10F mutation in PR20, L10I in PRS17 does not break the inter-subunit ion pair or diminish the dimer stability, consistent with a very low dimer dissociation constant comparable to that of wild type PR.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation