|
Mutation Information
|
Mutation Site
|
L10F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
27039930
|
|
Published Year
|
2016 |
|
Journal
|
Biochemistry |
|
Title
|
Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme. |
|
Author
|
Park JH,Sayer JM,Aniana A,Yu X,Weber IT,Harrison RW,Louis JM |
|
Evidence
|
Outside of the clusters, mutations L10F in PR20 and possibly L10I in PRS17 could disrupt the ion pair between R8 and D29' of the opposite subunit, resulting in altered conformation of the binding cavity.
|
|
|
HIV Mutation Detail Information