|
Mutation Information
|
Mutation Site
|
L109R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
|
Immune Escape
|
Y |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
17134939
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2007 |
|
Journal
|
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
|
Title
|
Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient. |
|
Author
|
Awerkiew S,Däumer M,Reiser M,Wend UC,Pfister H,Kaiser R,Willems WR,Gerlich WH |
|
Evidence
|
The virus exhibited three S gene mutations (L109R, C137W, G145R) which led to false negative HBsAg results and diminished binding of vaccine-induced anti-HBs.
|
|
|
HBV Mutation Detail Information