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Mutation Information
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Mutation Site
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L101M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
INSTIs |
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Country
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Africa |
Literature Information
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PubMed PMID
|
30891603
|
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Disease
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HIV infection/AIDS
|
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Published Year
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2019 |
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Journal
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The Journal of antimicrobial chemotherapy |
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Title
|
High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO. |
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Author
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Mboumba Bouassa RS,Mossoro-Kpinde CD,Gody JC,Veyer D,Péré H,Matta M,Robin L,Grésenguet G,Charpentier C,Bélec L |
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Evidence
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Polymorphic mutations in the IN gene were frequently observed: L101I/M, TT124A/G/N and T125A/P/V (100%) were the most represented, followed by G134D/N/S and L234I/P/V (94.4%); T112A/E/I/T/V (83.3%), D167E/N (77.7%), K136R/Q/T (66.7%), I72V (50.0%), S255D/G/N (38.9%), N222K/T, T206S and T218I/L/S (33.3%);and I135V, I208L and S119P (27.7%). Other polymorphic mutations were represented at <20% (Figure 2a).
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HIV Mutation Detail Information