|
Mutation Information
|
Mutation Site
|
L100I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
doravirine (DOR);efavirenz (EFV);nevirapine (NVP) |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
33943000
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
Journal of the International AIDS Society |
|
Title
|
Is there a role for doravirine in African HIV treatment programmes? A large observational resistance study in South Africa. |
|
Author
|
Steegen K,Moorhouse M,Wensing AM,Venter WD,Hans L |
|
Evidence
|
Exposure to efavirenz or nevirapine did not affect the prevalence of most DRMs, except for L100I, K103N/S and P225H, which were more frequently detected in efavirenz‐exposed patients (p = 0.0051, p = 0.0425 and p = 0.0476 respectively); whereas Y181C/I/V were more commonly detected in patients experiencing nevirapine‐based regimen failure (p = 0.0009).
|
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HIV Mutation Detail Information