HIV Mutation Detail Information

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Mutation Information

Mutation Site	L100I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs

Literature Information

PubMed PMID	32528834
Published Year	2020
Journal	Acta pharmaceutica Sinica. B
Title	Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs.
Author	Kang D,Feng D,Ginex T,Zou J,Wei F,Zhao T,Huang B,Sun Y,Desta S,De Clercq E,Pannecouque C,Zhan P,Liu X
Evidence	Especially, compound 26 exhibited the most potent activity against wild-type and a panel of single mutations (L100I, K103N, Y181C, Y188L and E138K) with an EC50 ranging from 6.02 to 23.9 nmol/L, which were comparable to those of etravirine (ETR).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation