Mutation Information
Mutation Site
|
L100I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Literature Information
PubMed PMID
|
32006797
|
Published Year
|
2020 |
Journal
|
Bioorganic chemistry |
Title
|
Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. |
Author
|
Sang Y,Pannecouque C,De Clercq E,Zhuang C,Chen F |
Evidence
|
Compound 51 displayed marked inhibitory activity against WT, and mutant L100I, K103N, Y181C, Y188L, and E138K HIV-1 mutants.
|
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