HIV Mutation Detail Information

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Mutation Information
Mutation Site L100I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Literature Information
PubMed PMID 32006797
Published Year 2020
Journal Bioorganic chemistry
Title Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Author Sang Y,Pannecouque C,De Clercq E,Zhuang C,Chen F
Evidence Compound 51 displayed marked inhibitory activity against WT, and mutant L100I, K103N, Y181C, Y188L, and E138K HIV-1 mutants.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation