|
Mutation Information
|
Mutation Site
|
L100I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
tenofovir (TDF);lamivudine (LAM);efavirenz (EFV) |
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
32005262
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS research and therapy |
|
Title
|
Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda. |
|
Author
|
Ayitewala A,Kyeyune F,Ainembabazi P,Nabulime E,Kato CD,Nankya I |
|
Evidence
|
Within the NNRTI class, G190 mutations (69.1%, p = 0.015), Y181C (78.6%, p = 0.008), L100I (82.4%, p = 0.019) were significantly more in the TDF/3TC/EFV group whereas mutation K238T (71.4%, p = 0.035) was significantly more in the AZT/3TC/EFV group (Fig. 2).
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HIV Mutation Detail Information