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Mutation Information
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Mutation Site
|
K88A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Tax |
Literature Information
|
PubMed PMID
|
10734308
|
|
Published Year
|
2000 |
|
Journal
|
Oncogene |
|
Title
|
HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration. |
|
Author
|
Ariumi Y,Kaida A,Lin JY,Hirota M,Masui O,Yamaoka S,Taya Y,Shimotohno K |
|
Evidence
|
However, Tax with a mutation in the coactivator CBP-binding site (K88A), which activates NF-kappaB but not the CREB pathway, could not repress the p53 trans-activation function.
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|
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HTLV1 Mutation Detail Information