HTLV1 Mutation Detail Information

> K88A Search Result

Mutation Information

Mutation Site	K88A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tax

Literature Information

PubMed PMID	10698501
Published Year	2000
Journal	Oncogene
Title	Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein.
Author	Kaida A,Ariumi Y,Ueda Y,Lin JY,Hijikata M,Ikawa S,Shimotohno K
Evidence	Moreover, a mutant Tax of coactivator CBP-binding site (K88A), which activated NF-kappaB but not CREB pathway, could not repress the p73 nor p51 trans-activation functions, indicating that CBP-binding domain of Tax is essential for the suppression of their functions.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation