HIV Mutation Detail Information

> K70T Search Result


Mutation Information
Mutation Site K70T
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug NRTIs
Country Zambia
Literature Information
PubMed PMID 32804970
Disease HIV infection/AIDS
Published Year 2020
Journal PloS one
Title Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia.
Author Miti S,Handema R,Mulenga L,Mwansa JK,Abrams E,Frimpong C,Burke VM,Zulu M,Siwingwa M,Mwakazanga D,Kalibala S,Denison JA
Evidence Common TAMs were K70RTQNE (32.8%), K219QE (22.4%), D67N (17.2%) and T215IT (15.5%). The most common NNRTI associated mutation was the K103N (65.5%) which confers resistance to both efavirenz (EFV) and nevirapine (NVP). There was a relatively high occurrence of other NNRTI mutations V106A (36.2%), as well as Y188C (36.2%) and Y181C (36.2%) which confer resistance to etravirine.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation