|
Mutation Information
|
Mutation Site
|
K70T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
|
Country
|
Zambia |
Literature Information
|
PubMed PMID
|
32804970
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
PloS one |
|
Title
|
Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia. |
|
Author
|
Miti S,Handema R,Mulenga L,Mwansa JK,Abrams E,Frimpong C,Burke VM,Zulu M,Siwingwa M,Mwakazanga D,Kalibala S,Denison JA |
|
Evidence
|
Common TAMs were K70RTQNE (32.8%), K219QE (22.4%), D67N (17.2%) and T215IT (15.5%). The most common NNRTI associated mutation was the K103N (65.5%) which confers resistance to both efavirenz (EFV) and nevirapine (NVP). There was a relatively high occurrence of other NNRTI mutations V106A (36.2%), as well as Y188C (36.2%) and Y181C (36.2%) which confer resistance to etravirine.
|
|
|
HIV Mutation Detail Information