HIV Mutation Detail Information

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Mutation Information

Mutation Site	K70T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	tenofovir (TFV)
Country	South Africa

Literature Information

PubMed PMID	31143879
Disease	HIV infection/AIDS
Published Year	2019
Journal	EClinicalMedicine
Title	Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis.
Author	Chimukangara B,Lessells RJ,Rhee SY,Giandhari J,Kharsany ABM,Naidoo K,Lewis L,Cawood C,Khanyile D,Ayalew KA,Diallo K,Samuel R,Hunt G,Vandormael A,Stray-Pedersen B,Gordon M,Makadzange T,Kiepiela P,Ramjee G,Ledwaba J,Kalimashe M,Morris L,Parikh UM,Mellors JW,Shafer RW,Katzenstein D,Moodley P,Gupta RK,Pillay D,Abdool Karim SS,de Oliveira T
Evidence	Twelve sequences had a TRAM not on the WHO SDRM list (A62V, n = 10;K70T, n = 2), although in four of these sequences the mutation was present with the K65R mutation.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation