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Mutation Information
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Mutation Site
|
K70R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
tenofovir alafenamide (TAF);tenofovir (TFV) |
|
Country
|
African heritage;Hispanic;Latino;Asian |
Literature Information
|
PubMed PMID
|
31988104
|
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Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Antiviral Activity of Tenofovir Alafenamide against HIV-1 with Thymidine Analog-Associated Mutations and M184V. |
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Author
|
Margot N,Ram R,Abram M,Haubrich R,Callebaut C |
|
Evidence
|
The susceptibilities to antiviral drugs of site-directed mutants (SDMs) and patient-derived mutants containing combinations of TAMs (M41L, D67N, K70R, L210W, T215Y, and K219Q) with or without the M184V mutation (TAMs+/-M184V) were evaluated using either 5-day multicycle (MC;n = 110) or 2-day single-cycle (SC;n = 96) HIV assays.
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HIV Mutation Detail Information