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Mutation Information
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Mutation Site
|
K70R |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
stavudine (D4T);zidovudine (AZT) |
|
Country
|
Cameroon |
Literature Information
|
PubMed PMID
|
30871487
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
BMC infectious diseases |
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Title
|
HIV-1 drug resistance testing is essential for heavily-treated patients switching from first- to second-line regimens in resource-limited settings: evidence from routine clinical practice in Cameroon. |
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Author
|
Takou D,Fokam J,Teto G,Santoro MM,Ceccherini-Silberstein F,Nanfack AJ,Sosso SM,Dambaya B,Salpini R,Billong SC,Gori C,Fokunang CN,Cappelli G,Colizzi V,Perno CF,Ndjolo A |
|
Evidence
|
Polymorphic mutations in the IN gene were frequently observed: L101I/M, TT124A/G/N and T125A/P/V (100%) were the most represented, followed by G134D/N/S and L234I/P/V (94.4%); T112A/E/I/T/V (83.3%), D167E/N (77.7%), K136R/Q/T (66.7%), I72V (50.0%), S255D/G/N (38.9%), N222K/T, T206S and T218I/L/S (33.3%);and I135V, I208L and S119P (27.7%).
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HIV Mutation Detail Information