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Mutation Information
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Mutation Site
|
K70R |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NRTIs |
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Country
|
Thailand |
Literature Information
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PubMed PMID
|
20158398
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2010 |
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Journal
|
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
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Title
|
Efficacy and safety of 1-month postpartum zidovudine-didanosine to prevent HIV-resistance mutations after intrapartum single-dose nevirapine. |
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Author
|
Lallemant M,Ngo-Giang-Huong N,Jourdain G,Traisaithit P,Cressey TR,Collins IJ,Jarupanich T,Sukhumanant T,Achalapong J,Sabsanong P,Chotivanich N,Winiyakul N,Ariyadej S,Kanjanasing A,Ratanakosol J,Hemvuttiphan J,Kengsakul K,Wannapira W,Sittipiyasakul V,Pornkitprasarn W,Liampongsabuddhi P,McIntosh K,Van Dyke RB,Frenkel LM,Koetsawang S,Le Coeur S,Kanchana S,PHPT-4 Study Team. |
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Evidence
|
After a median antepartum zidovudine duration of 10.4 weeks in both groups and an additional 4 weeks postpartum zidovudine-plus-didanosine in PHPT-4, new NRTI resistance mutations were detected by consensus sequencing in five PHPT-4 subjects (2.3%; four K70R and one D67N+K70R) and two PHPT-2 controls (0.9%; one D67N, one K70R) (Table 4).
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HIV Mutation Detail Information