HIV Mutation Detail Information

> K70N Search Result

Mutation Information

Mutation Site	K70N
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Country	sub‐Saharan Africa;South Asia;Southeast Asia;Latin America;Caribbean

Literature Information

PubMed PMID	32936523
Disease	HIV infection/AIDS
Published Year	2020
Journal	Journal of the International AIDS Society
Title	HIV-1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates.
Author	Rhee SY,Kassaye SG,Barrow G,Sundaramurthi JC,Jordan MR,Shafer RW
Evidence	Tenofovir resistance was defined as the presence of any one of the following four sets of mutations: (i) K65R, K70E and Y115F;(ii) the thymidine‐analogue mutations (TAMs) T215Y/F, which in contrast to the remaining TAMs reduce response to tenofovir‐containing regimens [14];(iii) the multidrug resistance mutations T69S_SS and Q151M and (iv) several additional non‐polymorphic DRMs not on the SDRM list including A62V, K65N, T69del and K70G/Q/N/S/T.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation