HIV Mutation Detail Information

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Mutation Information
Mutation Site K70N
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug tenofovir (TDF)
Country Vietnam;Zambia;Vietnam;Cameroon;Nicaragua;Uganda;Zambia;US
Literature Information
PubMed PMID 32694410
Disease HIV infection/AIDS
Published Year 2020
Journal AIDS (London, England)
Title Tenofovir resistance in early and long-term treated patients on first-line antiretroviral therapy in eight low-income and middle-income countries.
Author Inzaule SC,Jordan MR,Cournil A,Girón-Callejas A,Avila-Rios S,Mulenga L,Ssemwanga D,Asio J,Diop-Ndiaye H,Niasse-Traore F,Nhan DT,Dat VQ,Aghokeng AF,Billong S,Cham F,Doherty M,Bertagnolio S,Acquired HIV Drug Resistance Survey Team.
Evidence Overall, tenofovir resistance was mainly due to K65R or K70E/G/N/A/S/T/Y115F mutations (79%) but also due to thymidine analogue mutations (21%) which arise from exposure to thymidine analogues but causing cross-resistance to TDF.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation