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Mutation Information
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Mutation Site
|
K70E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
tenofovir (TDF) |
|
Country
|
Vietnam;Zambia;Vietnam;Cameroon;Nicaragua;Uganda;Zambia;US |
Literature Information
|
PubMed PMID
|
32694410
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Tenofovir resistance in early and long-term treated patients on first-line antiretroviral therapy in eight low-income and middle-income countries. |
|
Author
|
Inzaule SC,Jordan MR,Cournil A,Girón-Callejas A,Avila-Rios S,Mulenga L,Ssemwanga D,Asio J,Diop-Ndiaye H,Niasse-Traore F,Nhan DT,Dat VQ,Aghokeng AF,Billong S,Cham F,Doherty M,Bertagnolio S,Acquired HIV Drug Resistance Survey Team. |
|
Evidence
|
Overall, tenofovir resistance was mainly due to K65R or K70E/G/N/A/S/T/Y115F mutations (79%) but also due to thymidine analogue mutations (21%) which arise from exposure to thymidine analogues but causing cross-resistance to TDF.
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HIV Mutation Detail Information