|
Mutation Information
|
Mutation Site
|
K70E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
|
Country
|
Asia;Sub-saharan Africa;Europe;North America |
Literature Information
|
PubMed PMID
|
31774913
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I. |
|
Author
|
Gregson J,Rhee SY,Datir R,Pillay D,Perno CF,Derache A,Shafer RS,Gupta RK |
|
Evidence
|
Many of these mutations have previously been associated with drug resistance to tenofovir, either directly (K65R, K70E) or as compensatory mutations for K65R (A62V, S68N, F155Y).
|
|
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HIV Mutation Detail Information