|
Mutation Information
|
Mutation Site
|
K65R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
|
Country
|
sub Saharan Africa |
Literature Information
|
PubMed PMID
|
33262331
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Nature communications |
|
Title
|
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase. |
|
Author
|
Siedner MJ,Moorhouse MA,Simmons B,de Oliveira T,Lessells R,Giandhari J,Kemp SA,Chimukangara B,Akpomiemie G,Serenata CM,Venter WDF,Hill A,Gupta RK |
|
Evidence
|
Only 20 (2%) individuals had a nucleoside reverse transcriptase inhibitor (NRTI) mutation, with M184V being the most common, present in 12 (1%) individuals, followed by K65R, which was present in 8 (1%) individuals.
|
|
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HIV Mutation Detail Information