HIV Mutation Detail Information

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Mutation Information

Mutation Site	K65R
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	bictegravir (BIC);emtricitabine (FTC);tenofovir alafenamide (TAF);dolutegravir (DTG)

Literature Information

PubMed PMID	32701823
Disease	HIV infection/AIDS
Published Year	2020
Journal	Journal of acquired immune deficiency syndromes (1999)
Title	Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) From Dolutegravir (DTG)+F/TAF or DTG+F/Tenofovir Disoproxil Fumarate (TDF) in the Presence of Pre-existing NRTI Resistance.
Author	Acosta RK,Willkom M,Andreatta K,Liu H,Martin R,Parvangada A,Martin H,Collins S,White KL
Evidence	RESULTS: In total, 83% (470/565) of participants had baseline genotypic data available with NRTI-R detected in 24% (138/565), including 5% (30/565) with K65R/E/N or >/=3 thymidine analog mutations and 19% (108/565) with other NRTI-R mutations.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation