HIV Mutation Detail Information

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Mutation Information

Mutation Site	K65R
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	lamivudine (LAM)
Country	Spain

Literature Information

PubMed PMID	32408111
Disease	HIV infection/AIDS
Published Year	2020
Journal	EBioMedicine
Title	Dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: 48-week results of a non-randomized, pilot clinical trial (ART-PRO).
Author	De Miguel R,Rial-Crestelo D,Dominguez-Dominguez L,Montejano R,Esteban-Cantos A,Aranguren-Rivas P,Stella-Ascariz N,Bisbal O,Bermejo-Plaza L,Garcia-Alvarez M,Alejos B,Hernando A,Santacreu-Guerrero M,Cadiñanos J,Mayoral M,Castro JM,Moreno V,Martin-Carbonero L,Delgado R,Rubio R,Pulido F,Arribas JR,ART-PRO, PI16/00837-PI16/00678 study group.
Evidence	Baseline next-generation sequencing detected lamivudine resistance mutations (M184V/I and/or K65R/E/N) over a 5% threshold in 15/21 (71.4%) and 3/20 (15%) of participants with and without history of lamivudine resistance, respectively.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation