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Mutation Information
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Mutation Site
|
K65R |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
A |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
NRTIs |
Literature Information
|
PubMed PMID
|
31885806
|
|
Published Year
|
2019 |
|
Journal
|
Oxidative medicine and cellular longevity |
|
Title
|
HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist. |
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Author
|
Bayurova E,Jansons J,Skrastina D,Smirnova O,Mezale D,Kostyusheva A,Kostyushev D,Petkov S,Podschwadt P,Valuev-Elliston V,Sasinovich S,Korolev S,Warholm P,Latanova A,Starodubova E,Tukhvatulin A,Latyshev O,Selimov R,Metalnikov P,Komarov A,Ivanova O,Gorodnicheva T,Kochetkov S,Gottikh M,Strumfa I,Ivanov A,Gordeychuk I,Isaguliants M |
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Evidence
|
In in vitro tests, mutations of resistance to nucleoside inhibitors K65R/M184V reduced the polymerase, and to nonnucleoside inhibitors K103N/G190S, the RNase H activities of RT_A.
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HIV Mutation Detail Information