|
Mutation Information
|
Mutation Site
|
K65R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
tenofovir (TFV) |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
31143879
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
EClinicalMedicine |
|
Title
|
Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis. |
|
Author
|
Chimukangara B,Lessells RJ,Rhee SY,Giandhari J,Kharsany ABM,Naidoo K,Lewis L,Cawood C,Khanyile D,Ayalew KA,Diallo K,Samuel R,Hunt G,Vandormael A,Stray-Pedersen B,Gordon M,Makadzange T,Kiepiela P,Ramjee G,Ledwaba J,Kalimashe M,Morris L,Parikh UM,Mellors JW,Shafer RW,Katzenstein D,Moodley P,Gupta RK,Pillay D,Abdool Karim SS,de Oliveira T |
|
Evidence
|
We excluded 14 articles on the basis of our eligibility criteria: eight contained fewer than 10 HIV-1 pol sequences;two had only PR sequences with no RT sequences;one reported on a duplicate sequence dataset;one contained only sequences generated from samples collected prior to 2000;one was based on targeted sequencing for a single mutation (K65R);and sequences were unavailable for one study (Appendix, p 5).
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HIV Mutation Detail Information