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Mutation Information
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Mutation Site
|
K65R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
NRTIs |
Literature Information
|
PubMed PMID
|
19918107
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2009 |
|
Journal
|
Antiviral therapy |
|
Title
|
Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop. |
|
Author
|
Mascolini M,Boucher CA,Mellors JW,Larder BA,Richman DD |
|
Evidence
|
The XVIII workshop featured work on HIV type-1 (HIV-1) persistence, reservoirs and elimination strategies;resistance to HIV-1 entry inhibitors (including a comparison of genotyping versus phenotyping to determine HIV-1 coreceptor use before treatment with CCR5 antagonists);polymerase domain resistance to reverse transcriptase inhibitors (including hepatitis B virus and HIV-1 resistance to lamivudine, and emergence of the K65R mutation in HIV-1 subtypes B and C);connection and RNase H domain resistance to reverse transcriptase inhibitors (including the effect of mutations in those domains on response to efavirenz and etravirine);resistance to hepatitis C virus and HIV-1 protease inhibitors;resistance to the integrase inhibitor raltegravir;global resistance epidemiology (including models to predict response to second-line antiretrovirals in resource-poor settings);and the role of minority resistant variants (including the effect of such variants on prevention of mother-to-child transmission of HIV-1).
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HIV Mutation Detail Information