|
Mutation Information
|
Mutation Site
|
K65R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
hexadecyloxypropyl-(S)-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine[HDP-(S)-HPMPA] |
Literature Information
|
PubMed PMID
|
16870786
|
|
Published Year
|
2006 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro. |
|
Author
|
Hostetler KY,Aldern KA,Wan WB,Ciesla SL,Beadle JR |
|
Evidence
|
Resistance to HDP-(S)-HPMPA and ODE-(S)-HPMPA was noted for a mutant with mutation K65R.
|
|
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HIV Mutation Detail Information