|
Mutation Information
|
Mutation Site
|
K65E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
33200210
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Long-term efficacy of dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: Week 96 results of ART-PRO pilot study. |
|
Author
|
Rial-Crestelo D,de Miguel R,Montejano R,Dominguez-Dominguez L,Aranguren-Rivas P,Esteban-Cantos A,Bisbal O,Santacreu-Guerrero M,Garcia-Alvarez M,Alejos B,Hernando A,Bermejo-Plaza L,Cadiñanos J,Mayoral M,Castro JM,Moreno V,Martin-Carbonero L,Delgado R,Rubio R,Pulido F,Arribas JR,ART-PRO .,PI16/00837-PI16/00678 study group . |
|
Evidence
|
Baseline proviral DNA NGS detected lamivudine RAMs (M184V/I and/or K65R/E/N) above a 5% threshold in 71.4% (15/21) and 15% (3/20) of participants with and without history of lamivudine resistance, respectively.
|
|
|
HIV Mutation Detail Information