Mutation Information
Mutation Site
|
K601E |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Env |
Viral Reference
|
K03455.1
|
Relevant Drug
|
T1249;T2635;VIR165 |
Literature Information
PubMed PMID
|
30696772
|
Published Year
|
2019 |
Journal
|
The Journal of biological chemistry |
Title
|
HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry. |
Author
|
Eggink D,Bontjer I,de Taeye SW,Langedijk JPM,Berkhout B,Sanders RW |
Evidence
|
Substitutions located at the edge (Q577R) or outside the binding site of HR2-based fusion inhibitors (Q590E, K601E, and N637K) provide resistance to the more potent second and third generation peptides T1249 and T2635.
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