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Mutation Information
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Mutation Site
|
K588E |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Env |
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Combined Mutation
|
env.E647G+env.N637K+env.K588E;env.E662G+env.N637K+gp41.T605N+env.K588N+env.L544S |
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Viral Reference
|
K03455.1
|
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Relevant Drug
|
T2635 |
Literature Information
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PubMed PMID
|
30696772
|
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Published Year
|
2019 |
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Journal
|
The Journal of biological chemistry |
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Title
|
HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry. |
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Author
|
Eggink D,Bontjer I,de Taeye SW,Langedijk JPM,Berkhout B,Sanders RW |
|
Evidence
|
The K588E, Q590E, and K601E mutant viruses showed the most substantial decrease in thermal stability compared with WT virus, with Tm values of 40.8, 41.1, and 40.8 °C, respectively, versus 43.6 °C for WT virus (Fig. 3B).
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HIV Mutation Detail Information