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Mutation Information
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Mutation Site
|
K51A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Tat |
Literature Information
|
PubMed PMID
|
18498648
|
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Published Year
|
2008 |
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Journal
|
Retrovirology |
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Title
|
Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR. |
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Author
|
Van Duyne R,Easley R,Wu W,Berro R,Pedati C,Klase Z,Kehn-Hall K,Flynn EK,Symer DE,Kashanchi F |
|
Evidence
|
Purified SETDB1 enzyme was incubated with either no substrate, histone H3 N-terminal peptide mutated at all 8 lysines (residues 2-37), four core histones or WT Tat protein as a control as well as Tat mutant peptides: K50A, K51A, and K5051A.
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HIV Mutation Detail Information