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Mutation Information
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Mutation Site
|
K50E |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vif |
Literature Information
|
PubMed PMID
|
32471198
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Structural Insights into APOBEC3-Mediated Lentiviral Restriction. |
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Author
|
Delviks-Frankenberry KA,Desimmie BA,Pathak VK |
|
Evidence
|
Vif mutant K50E was severely defective in inducing A3F degradation or rescuing virus infectivity in single cycle assays and as shown previously, A3F mutant E289K was highly resistant to degradation by WT Vif.
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HIV Mutation Detail Information