HIV Mutation Detail Information

> K476N Search Result

Mutation Information

Mutation Site	K476N
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	3'-azido-2',3'-dideoxyguanosine (3'-azido-ddG)

Literature Information

PubMed PMID	24211331
Published Year	2014
Journal	Antiviral research
Title	Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine.
Author	Meteer JD,Schinazi RF,Mellors JW,Sluis-Cremer N
Evidence	We reported that 3'-azido-2',3'-dideoxyguanosine (3'-azido-ddG) selected for the L74V, F77L, and L214F mutations in the polymerase domain and K476N and V518I mutations in the RNase H domain of HIV-1 reverse transcriptase (RT).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation